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Genome-Wide Association Study for Circulating Tissue Plasminogen Activator (tPA) Levels and Functional Follow-up Implicates Endothelial STXBP5 and STX2

Identifieur interne : 003915 ( Main/Exploration ); précédent : 003914; suivant : 003916

Genome-Wide Association Study for Circulating Tissue Plasminogen Activator (tPA) Levels and Functional Follow-up Implicates Endothelial STXBP5 and STX2

Auteurs : Jie Huang [États-Unis] ; Jennifer E. Huffman [Royaume-Uni] ; Munekazu Yamkauchi [États-Unis] ; Stella Trompet [Pays-Bas] ; Folkert W. Asselbergs [Pays-Bas, Royaume-Uni] ; Maria Sabater-Lleal [Suède] ; David-Alexandre Trégouët [France] ; Wei-Min Chen [États-Unis] ; Nicholas L. Smith [États-Unis] ; Marcus E. Kleber [Allemagne] ; So-Youn Shin [Royaume-Uni] ; Diane M. Becker [États-Unis] ; Weihong Tang [États-Unis] ; Abbas Dehghan [Pays-Bas] ; Andrew D. Johnson [États-Unis] ; Vinh Truong [France] ; Lasse Folkersen [Suède] ; Qiong Yang [États-Unis] ; Tiphaine Oudot-Mellakh [France] ; Brendan M. Buckley [Irlande (pays)] ; Jason H. Moore [États-Unis] ; Frances M. K. Williams [Royaume-Uni] ; Harry Campbell [Royaume-Uni] ; Günther Silbernagel [Suisse] ; Veronique Vitart [Royaume-Uni] ; Igor Rudan [Royaume-Uni] ; Geoffrey H. Tofler [Australie] ; Gerjan J. Navis [Pays-Bas] ; Anita Destefano [États-Unis] ; Alan F. Wright [Royaume-Uni] ; Ming-Huei Chen [États-Unis] ; Anton J. M. De Craen [Pays-Bas] ; Bradford B. Worrall [États-Unis] ; Alicja R. Rudnicka [Royaume-Uni] ; Ann Rumley [Royaume-Uni] ; Ebony B. Bookman [États-Unis] ; Bruce M. Psaty [États-Unis] ; Fang Chen [États-Unis] ; Keith L. Keene [États-Unis] ; Oscar H. Franco [Pays-Bas] ; Bernhard O. Böhm [Allemagne] ; Andre G. Uitterlinden [Pays-Bas] ; Angela M. Carter [Royaume-Uni] ; J. Wouter Jukema [Pays-Bas] ; Naveed Sattar [Royaume-Uni] ; Joshua C. Bis [États-Unis] ; Mohammad A. Ikram [Pays-Bas] ; Michèle M. Sale [États-Unis] ; Barbara Mcknight [États-Unis] ; Myriam Fornage [États-Unis] ; Ian Ford [Royaume-Uni] ; Kent Taylor [États-Unis] ; P. Eline Slagboom [Pays-Bas] ; Wendy L. Mcardle [Royaume-Uni] ; Fang-Chi Hsu [États-Unis] ; Anders Franco-Cereceda [Suède] ; Alison H. Goodall [Royaume-Uni] ; Lisa R. Yanek [États-Unis] ; Karen L. Furie [États-Unis] ; Mary Cushman [États-Unis] ; Albert Hofman [Pays-Bas] ; Jacqueline Cm. Witteman [Pays-Bas] ; Aaron R. Folsom [États-Unis] ; Saonli Basu [États-Unis] ; Nena Matijevic [États-Unis] ; Wiek H. Van Gilst [Pays-Bas] ; James F. Wilson [Royaume-Uni] ; Rudi G. J. Westendorp [Pays-Bas] ; Sekar Kathiresan [États-Unis] ; Muredach P. Reilly [États-Unis] ; Russell P. Tracy [États-Unis] ; Ozren Polasek [Croatie] ; Bernhard R. Winkelmann [Allemagne] ; Peter J. Grant [Pays-Bas] ; Hans L. Hillege [Pays-Bas] ; Francois Cambien [France] ; David J. Stott [Royaume-Uni] ; Gordon D. Lowe [Royaume-Uni] ; Timothy D. Spector [Royaume-Uni] ; James B. Meigs [États-Unis] ; Winfried Marz [Allemagne] ; Per Eriksson [Suède] ; Lewis C. Becker [États-Unis] ; Pierre-Emmanuel Morange [France] ; Nicole Soranzo [Royaume-Uni] ; Scott M. Williams [États-Unis] ; Caroline Hayward [Royaume-Uni] ; Pim Van Der Harst [Pays-Bas] ; Anders Hamsten [Suède] ; Charles J. Lowenstein [États-Unis] ; David P. Strachan [Royaume-Uni] ; Christopher J. O'Donnell [États-Unis]

Source :

RBID : PMC:4009733

Abstract

Objective

Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases (CVD). We conducted a meta-analysis of genome-wide association studies (GWAS) to identify novel correlates of circulating levels of tPA.

Approach and Results

Fourteen cohort studies with tPA measures (N=26,929) contributed to the meta-analysis. Three loci were significantly associated with circulating tPA levels (P <5.0×10−8). The first locus is on 6q24.3, with the lead SNP (rs9399599, P=2.9×10−14) within STXBP5. The second locus is on 8p11.21. The lead SNP (rs3136739, P=1.3×10−9) is intronic to POLB and less than 200kb away from the tPA encoding gene PLAT. We identified a non-synonymous SNP (rs2020921) in modest LD with rs3136739 (r2 = 0.50) within exon 5 of PLAT (P=2.0×10−8). The third locus is on 12q24.33, with the lead SNP (rs7301826, P=1.0×10−9) within intron 7 of STX2. We further found evidence for association of lead SNPs in STXBP5 and STX2 with expression levels of the respective transcripts. In in vitro cell studies, silencing STXBP5 decreased release of tPA from vascular endothelial cells, while silencing of STX2 increased tPA release. Through an in-silico lookup, we found no associations of the three lead SNPs with coronary artery disease or stroke.

Conclusions

We identified three loci associated with circulating tPA levels, the PLAT region, STXBP5 and STX2. Our functional studies implicate a novel role for STXBP5 and STX2 in regulating tPA release.


Url:
DOI: 10.1161/ATVBAHA.113.302088
PubMed: 24578379
PubMed Central: 4009733


Affiliations:

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Le document en format XML

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<name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name>
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<country xml:lang="fr">Allemagne</country>
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<name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name>
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<name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
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<country xml:lang="fr">États-Unis</country>
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<region type="state">Maryland</region>
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<name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
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<region type="state">Minnesota</region>
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<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
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<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
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<settlement type="city">Leyde</settlement>
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<name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
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<nlm:aff id="A1">National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham</wicri:cityArea>
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<name sortKey="Truong, Vinh" sort="Truong, Vinh" uniqKey="Truong V" first="Vinh" last="Truong">Vinh Truong</name>
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<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
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<nlm:aff id="A12">ICAN Institute for Cardiometabolism and Nutrion, Paris, France</nlm:aff>
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</affiliation>
</author>
<author>
<name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name>
<affiliation wicri:level="3">
<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
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<author>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
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</author>
<author>
<name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
<affiliation wicri:level="3">
<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
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<author>
<name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
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<nlm:aff id="A26">Department of Pharmacology and Therapeutics, University College Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork</wicri:regionArea>
<wicri:noRegion>University College Cork</wicri:noRegion>
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</author>
<author>
<name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
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<nlm:aff id="A27">Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH</wicri:regionArea>
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<region type="state">New Hampshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A28">Department of Community and Family Medicine, Gesiel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Community and Family Medicine, Gesiel School of Medicine at Dartmouth, Lebanon, NH</wicri:regionArea>
<placeName>
<region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
<affiliation wicri:level="3">
<nlm:aff id="A31">Department of Angiology, Swiss Cardiovascular Center, Inselspital Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Angiology, Swiss Cardiovascular Center, Inselspital Bern, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4">
<nlm:aff id="A32">Royal North Shore Hospital, University of Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name>
<affiliation wicri:level="3">
<nlm:aff id="A33">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
<wicri:noRegion>Mass</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
<wicri:noRegion>Mass</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B." last="Worrall">Bradford B. Worrall</name>
<affiliation wicri:level="2">
<nlm:aff id="A13">Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
<affiliation wicri:level="4">
<nlm:aff id="A34">Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bookman, Ebony B" sort="Bookman, Ebony B" uniqKey="Bookman E" first="Ebony B." last="Bookman">Ebony B. Bookman</name>
<affiliation wicri:level="2">
<nlm:aff id="A36">Division of Genomic Medicine, NHGRI, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genomic Medicine, NHGRI, Bethesda, MD</wicri:regionArea>
<placeName>
<region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="2">
<nlm:aff id="A14">Department of Epidemiology, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Washington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A15">Group Health Research Institute, Group Health Cooperative, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Group Health Research Institute, Group Health Cooperative</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A37">Department of Medicine, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A38">Department of Health Services, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Health Services, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Chen, Fang" sort="Chen, Fang" uniqKey="Chen F" first="Fang" last="Chen">Fang Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="A13">Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Biology and Center for Health Disparities Research, East Carolina University, Greenville, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology and Center for Health Disparities Research, East Carolina University, Greenville, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bohm, Bernhard O" sort="Bohm, Bernhard O" uniqKey="Bohm B" first="Bernhard O." last="Böhm">Bernhard O. Böhm</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, Ulm University Medical Centre, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A41">LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Singapore and Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A42">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Cardiology, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A44">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A45">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Department of Medicine, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, Mohammad A" sort="Ikram, Mohammad A" uniqKey="Ikram M" first="Mohammad A." last="Ikram">Mohammad A. Ikram</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A47">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A48">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michèle M." last="Sale">Michèle M. Sale</name>
<affiliation wicri:level="2">
<nlm:aff id="A49">Center for Public Health Genomics, Department of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation wicri:level="2">
<nlm:aff id="A14">Department of Epidemiology, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2">
<nlm:aff id="A50">Brown Foundation Institute of Molecular Medicine and Human Genetics Center, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brown Foundation Institute of Molecular Medicine and Human Genetics Center, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4">
<nlm:aff id="A51">Robertson Center for Biostatistics, University of Glasgow, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow</wicri:regionArea>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author>
<name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2">
<nlm:aff id="A52">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A53">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">ALSPAC Laboratory, Department of Social Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>ALSPAC Laboratory, Department of Social Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea>
<wicri:noRegion>Bristol BS8 2BN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hsu, Fang Chi" sort="Hsu, Fang Chi" uniqKey="Hsu F" first="Fang-Chi" last="Hsu">Fang-Chi Hsu</name>
<affiliation wicri:level="2">
<nlm:aff id="A55">Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name>
<affiliation wicri:level="3">
<nlm:aff id="A56">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation wicri:level="2">
<nlm:aff id="A21">Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore, MD 21287 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name>
<affiliation wicri:level="2">
<nlm:aff id="A58">The Warren Alpert Medical School of Brown University, Providence, RI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Warren Alpert Medical School of Brown University, Providence, RI</wicri:regionArea>
<placeName>
<region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation wicri:level="2">
<nlm:aff id="A59">Department of Medicine, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A60">Department of Pathology, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Witteman, Jacqueline Cm" sort="Witteman, Jacqueline Cm" uniqKey="Witteman J" first="Jacqueline Cm." last="Witteman">Jacqueline Cm. Witteman</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2">
<nlm:aff id="A22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2">
<nlm:aff id="A61">Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<affiliation wicri:level="2">
<nlm:aff id="A62">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="3">
<nlm:aff id="A63">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G. J." last="Westendorp">Rudi G. J. Westendorp</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2">
<nlm:aff id="A64">Cardiology Division, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiology Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A65">Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A66">Center for Human Genetic Research,Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetic Research,Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A67">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2">
<nlm:aff id="A68">The Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<affiliation wicri:level="2">
<nlm:aff id="A60">Department of Pathology, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, Faculty of Medicine, University of Split</wicri:regionArea>
<wicri:noRegion>University of Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name>
<affiliation wicri:level="3">
<nlm:aff id="A70">Cardiology Team Sachsenhausen, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cardiology Team Sachsenhausen, Frankfurt am Main</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name>
<affiliation wicri:level="3">
<nlm:aff id="A42">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="3">
<nlm:aff id="A63">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="3">
<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A12">ICAN Institute for Cardiometabolism and Nutrion, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrion, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<affiliation wicri:level="2">
<nlm:aff id="A71">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A72">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea>
<wicri:noRegion>Massachusetts 02115</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Marz, Winfried" sort="Marz, Winfried" uniqKey="Marz W" first="Winfried" last="Marz">Winfried Marz</name>
<affiliation wicri:level="3">
<nlm:aff id="A18">Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A73">Synlab Academy, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Synlab Academy, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A74">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz Austria</nlm:aff>
<wicri:noCountry code="subfield">Graz Austria</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3">
<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name>
<affiliation wicri:level="2">
<nlm:aff id="A21">Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore, MD 21287 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4">
<nlm:aff id="A75">INSERM UMRS_1062, Aix-Marseille Université, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMRS_1062, Aix-Marseille Université, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
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<country xml:lang="fr">Suède</country>
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<placeName>
<region type="state">État de New York</region>
</placeName>
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<region type="state">Massachusetts</region>
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<name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
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<nlm:aff id="A1">National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA USA</nlm:aff>
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<name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name>
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<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
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<name sortKey="Yamkauchi, Munekazu" sort="Yamkauchi, Munekazu" uniqKey="Yamkauchi M" first="Munekazu" last="Yamkauchi">Munekazu Yamkauchi</name>
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<nlm:aff id="A4">The Aab Cardiovascular Research Institute, Department of Medicine, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, NY USA</nlm:aff>
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<placeName>
<region type="state">État de New York</region>
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<wicri:cityArea>The Aab Cardiovascular Research Institute, Department of Medicine, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester</wicri:cityArea>
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<name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Cardiology, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
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<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
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<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="3">
<nlm:aff id="A7">Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht</wicri:regionArea>
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<affiliation wicri:level="3">
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht</wicri:regionArea>
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<settlement type="city">Utrecht</settlement>
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</affiliation>
<affiliation wicri:level="4">
<nlm:aff id="A9">Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London</wicri:regionArea>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
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<settlement type="city">Londres</settlement>
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<name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name>
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<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
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<settlement type="city">Stockholm</settlement>
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<name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name>
<affiliation wicri:level="3">
<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A12">ICAN Institute for Cardiometabolism and Nutrion, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrion, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="A13">Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea>
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<region type="state">Virginie</region>
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<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<affiliation wicri:level="2">
<nlm:aff id="A14">Department of Epidemiology, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
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<affiliation wicri:level="2">
<nlm:aff id="A15">Group Health Research Institute, Group Health Cooperative, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Group Health Research Institute, Group Health Cooperative</wicri:cityArea>
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<affiliation wicri:level="1">
<nlm:aff id="A16">Seattle Epidemiologic Research & Information Center, VA Office of Research & Development, Seattle WA 98108, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Seattle Epidemiologic Research & Information Center, VA Office of Research & Development, Seattle WA 98108</wicri:regionArea>
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<author>
<name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E." last="Kleber">Marcus E. Kleber</name>
<affiliation wicri:level="3">
<nlm:aff id="A17">Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II – Cardiology, University of Ulm Medical Centre, Ulm</wicri:regionArea>
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<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
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</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A18">Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
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<affiliation wicri:level="1">
<nlm:aff id="A20">MRC Centre for CAiTE, School of Social and Community Medicine, University of Bristol, Bristol, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Centre for CAiTE, School of Social and Community Medicine, University of Bristol, Bristol</wicri:regionArea>
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</author>
<author>
<name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<affiliation wicri:level="2">
<nlm:aff id="A21">Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore, MD 21287 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore</wicri:cityArea>
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</author>
<author>
<name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<affiliation wicri:level="2">
<nlm:aff id="A22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea>
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<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
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<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<affiliation wicri:level="2">
<nlm:aff id="A1">National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation>
<nlm:aff id="A2">National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda MD USA</nlm:aff>
<wicri:noCountry code="subfield">Bethesda MD USA</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Truong, Vinh" sort="Truong, Vinh" uniqKey="Truong V" first="Vinh" last="Truong">Vinh Truong</name>
<affiliation wicri:level="3">
<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
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<affiliation wicri:level="3">
<nlm:aff id="A12">ICAN Institute for Cardiometabolism and Nutrion, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrion, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Folkersen, Lasse" sort="Folkersen, Lasse" uniqKey="Folkersen L" first="Lasse" last="Folkersen">Lasse Folkersen</name>
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<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
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<settlement type="city">Stockholm</settlement>
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</placeName>
</affiliation>
</author>
<author>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
<wicri:noRegion>Mass</wicri:noRegion>
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</author>
<author>
<name sortKey="Oudot Mellakh, Tiphaine" sort="Oudot Mellakh, Tiphaine" uniqKey="Oudot Mellakh T" first="Tiphaine" last="Oudot-Mellakh">Tiphaine Oudot-Mellakh</name>
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<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author>
<name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation wicri:level="1">
<nlm:aff id="A26">Department of Pharmacology and Therapeutics, University College Cork, Ireland</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Department of Pharmacology and Therapeutics, University College Cork</wicri:regionArea>
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</author>
<author>
<name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<affiliation wicri:level="2">
<nlm:aff id="A27">Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH</wicri:regionArea>
<placeName>
<region type="state">New Hampshire</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A28">Department of Community and Family Medicine, Gesiel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Community and Family Medicine, Gesiel School of Medicine at Dartmouth, Lebanon, NH</wicri:regionArea>
<placeName>
<region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Silbernagel, Gunther" sort="Silbernagel, Gunther" uniqKey="Silbernagel G" first="Günther" last="Silbernagel">Günther Silbernagel</name>
<affiliation wicri:level="3">
<nlm:aff id="A31">Department of Angiology, Swiss Cardiovascular Center, Inselspital Bern, Bern, Switzerland</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea>Department of Angiology, Swiss Cardiovascular Center, Inselspital Bern, Bern</wicri:regionArea>
<placeName>
<settlement type="city">Berne</settlement>
<region type="région" nuts="3">Canton de Berne</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tofler, Geoffrey H" sort="Tofler, Geoffrey H" uniqKey="Tofler G" first="Geoffrey H." last="Tofler">Geoffrey H. Tofler</name>
<affiliation wicri:level="4">
<nlm:aff id="A32">Royal North Shore Hospital, University of Sydney, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Royal North Shore Hospital, University of Sydney</wicri:regionArea>
<placeName>
<settlement type="city">Sydney</settlement>
<region type="état">Nouvelle-Galles du Sud</region>
</placeName>
<orgName type="university">Université de Sydney</orgName>
</affiliation>
</author>
<author>
<name sortKey="Navis, Gerjan J" sort="Navis, Gerjan J" uniqKey="Navis G" first="Gerjan J." last="Navis">Gerjan J. Navis</name>
<affiliation wicri:level="3">
<nlm:aff id="A33">Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
<wicri:noRegion>Mass</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="1">
<nlm:aff id="A25">Department of Biostatistics, Boston University, Boston, Mass, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University, Boston, Mass</wicri:regionArea>
<wicri:noRegion>Mass</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B." last="Worrall">Bradford B. Worrall</name>
<affiliation wicri:level="2">
<nlm:aff id="A13">Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
<affiliation wicri:level="4">
<nlm:aff id="A34">Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bookman, Ebony B" sort="Bookman, Ebony B" uniqKey="Bookman E" first="Ebony B." last="Bookman">Ebony B. Bookman</name>
<affiliation wicri:level="2">
<nlm:aff id="A36">Division of Genomic Medicine, NHGRI, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Genomic Medicine, NHGRI, Bethesda, MD</wicri:regionArea>
<placeName>
<region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<affiliation wicri:level="2">
<nlm:aff id="A14">Department of Epidemiology, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Washington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A15">Group Health Research Institute, Group Health Cooperative, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Group Health Research Institute, Group Health Cooperative</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A37">Department of Medicine, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A38">Department of Health Services, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Health Services, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Chen, Fang" sort="Chen, Fang" uniqKey="Chen F" first="Fang" last="Chen">Fang Chen</name>
<affiliation wicri:level="2">
<nlm:aff id="A13">Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name>
<affiliation wicri:level="2">
<nlm:aff id="A39">Department of Biology and Center for Health Disparities Research, East Carolina University, Greenville, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology and Center for Health Disparities Research, East Carolina University, Greenville, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Bohm, Bernhard O" sort="Bohm, Bernhard O" uniqKey="Bohm B" first="Bernhard O." last="Böhm">Bernhard O. Böhm</name>
<affiliation wicri:level="3">
<nlm:aff id="A40">Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine I, Ulm University Medical Centre, Ulm</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Ulm</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A41">LKC School of Medicine, Nanyang Technological University, Singapore and Imperial College London</nlm:aff>
<wicri:noCountry code="subfield">Singapore and Imperial College London</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A42">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name>
<affiliation wicri:level="1">
<nlm:aff id="A43">Division of Cardiovascular and Diabetes Research, Leeds University, Leeds, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Cardiovascular and Diabetes Research, Leeds University, Leeds</wicri:regionArea>
<wicri:noRegion>Leeds</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="1">
<nlm:aff id="A5">Department of Cardiology, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A44">Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, Amsterdam</wicri:regionArea>
<placeName>
<settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A45">Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Interuniversity Cardiology Institute of the Netherlands, Utrecht</wicri:regionArea>
<placeName>
<settlement type="city">Utrecht</settlement>
<region nuts="2" type="province">Utrecht (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<affiliation wicri:level="1">
<nlm:aff id="A46">BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow</wicri:regionArea>
<wicri:noRegion>Glasgow</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="2">
<nlm:aff id="A37">Department of Medicine, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Ikram, Mohammad A" sort="Ikram, Mohammad A" uniqKey="Ikram M" first="Mohammad A." last="Ikram">Mohammad A. Ikram</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A47">Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A48">Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michèle M." last="Sale">Michèle M. Sale</name>
<affiliation wicri:level="2">
<nlm:aff id="A49">Center for Public Health Genomics, Department of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Public Health Genomics, Department of Medicine, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA</wicri:regionArea>
<placeName>
<region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<affiliation wicri:level="2">
<nlm:aff id="A14">Department of Epidemiology, University of Washington, Seattle WA 98101 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Washington (État)</region>
</placeName>
<wicri:cityArea>Department of Epidemiology, University of Washington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2">
<nlm:aff id="A50">Brown Foundation Institute of Molecular Medicine and Human Genetics Center, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brown Foundation Institute of Molecular Medicine and Human Genetics Center, Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation wicri:level="4">
<nlm:aff id="A51">Robertson Center for Biostatistics, University of Glasgow, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Robertson Center for Biostatistics, University of Glasgow</wicri:regionArea>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
<orgName type="university">Université de Glasgow</orgName>
</affiliation>
</author>
<author>
<name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<affiliation wicri:level="2">
<nlm:aff id="A52">Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048</wicri:regionArea>
<placeName>
<region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P. Eline" last="Slagboom">P. Eline Slagboom</name>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A53">Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<affiliation wicri:level="1">
<nlm:aff id="A54">ALSPAC Laboratory, Department of Social Medicine, University of Bristol, Bristol BS8 2BN, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>ALSPAC Laboratory, Department of Social Medicine, University of Bristol, Bristol BS8 2BN</wicri:regionArea>
<wicri:noRegion>Bristol BS8 2BN</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hsu, Fang Chi" sort="Hsu, Fang Chi" uniqKey="Hsu F" first="Fang-Chi" last="Hsu">Fang-Chi Hsu</name>
<affiliation wicri:level="2">
<nlm:aff id="A55">Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea>
<placeName>
<region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Franco Cereceda, Anders" sort="Franco Cereceda, Anders" uniqKey="Franco Cereceda A" first="Anders" last="Franco-Cereceda">Anders Franco-Cereceda</name>
<affiliation wicri:level="3">
<nlm:aff id="A56">Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<affiliation wicri:level="1">
<nlm:aff id="A57">Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester</wicri:regionArea>
<wicri:noRegion>Leicester</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<affiliation wicri:level="2">
<nlm:aff id="A21">Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore, MD 21287 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name>
<affiliation wicri:level="2">
<nlm:aff id="A58">The Warren Alpert Medical School of Brown University, Providence, RI, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Warren Alpert Medical School of Brown University, Providence, RI</wicri:regionArea>
<placeName>
<region type="state">Rhode Island</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<affiliation wicri:level="2">
<nlm:aff id="A59">Department of Medicine, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Medicine, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A60">Department of Pathology, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Witteman, Jacqueline Cm" sort="Witteman, Jacqueline Cm" uniqKey="Witteman J" first="Jacqueline Cm." last="Witteman">Jacqueline Cm. Witteman</name>
<affiliation wicri:level="3">
<nlm:aff id="A23">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<affiliation wicri:level="2">
<nlm:aff id="A22">Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<affiliation wicri:level="2">
<nlm:aff id="A61">Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Biostatistics, University of Minnesota, Minneapolis, MN</wicri:regionArea>
<placeName>
<region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<affiliation wicri:level="2">
<nlm:aff id="A62">Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, Texas, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Hemostasis Laboratory, University of Texas Health Science Center at Houston, Houston, Texas</wicri:regionArea>
<placeName>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Van Gilst, Wiek H" sort="Van Gilst, Wiek H" uniqKey="Van Gilst W" first="Wiek H." last="Van Gilst">Wiek H. Van Gilst</name>
<affiliation wicri:level="3">
<nlm:aff id="A63">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation wicri:level="4">
<nlm:aff id="A30">Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName>
<settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Westendorp, Rudi G J" sort="Westendorp, Rudi G J" uniqKey="Westendorp R" first="Rudi G. J." last="Westendorp">Rudi G. J. Westendorp</name>
<affiliation wicri:level="1">
<nlm:aff id="A6">Department of Gerontology and Geriatrics, Leiden University Medical Center, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Gerontology and Geriatrics, Leiden University Medical Center</wicri:regionArea>
<wicri:noRegion>Leiden University Medical Center</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A24">Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium of Healthy Aging sponsored by Netherlands Genomics Initiative, Leiden</wicri:regionArea>
<placeName>
<settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<affiliation wicri:level="2">
<nlm:aff id="A64">Cardiology Division, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiology Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A65">Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A66">Center for Human Genetic Research,Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Human Genetic Research,Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A67">Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2">
<nlm:aff id="A68">The Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<affiliation wicri:level="2">
<nlm:aff id="A60">Department of Pathology, University of Vermont, Burlington, VT 05405 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Vermont</region>
</placeName>
<wicri:cityArea>Department of Pathology, University of Vermont, Burlington</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1">
<nlm:aff id="A69">Department of Public Health, Faculty of Medicine, University of Split, Croatia</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea>Department of Public Health, Faculty of Medicine, University of Split</wicri:regionArea>
<wicri:noRegion>University of Split</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Winkelmann, Bernhard R" sort="Winkelmann, Bernhard R" uniqKey="Winkelmann B" first="Bernhard R." last="Winkelmann">Bernhard R. Winkelmann</name>
<affiliation wicri:level="3">
<nlm:aff id="A70">Cardiology Team Sachsenhausen, Frankfurt am Main, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Cardiology Team Sachsenhausen, Frankfurt am Main</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Hesse (Land)</region>
<region type="district" nuts="2">District de Darmstadt</region>
<settlement type="city">Francfort-sur-le-Main</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name>
<affiliation wicri:level="3">
<nlm:aff id="A42">Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName>
<settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="3">
<nlm:aff id="A63">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Cambien, Francois" sort="Cambien, Francois" uniqKey="Cambien F" first="Francois" last="Cambien">Francois Cambien</name>
<affiliation wicri:level="3">
<nlm:aff id="A11">INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMR_S 937 ; Pierre et Marie Curie University, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A12">ICAN Institute for Cardiometabolism and Nutrion, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>ICAN Institute for Cardiometabolism and Nutrion, Paris</wicri:regionArea>
<placeName>
<region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<affiliation wicri:level="4">
<nlm:aff id="A35">Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName>
<settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<affiliation wicri:level="2">
<nlm:aff id="A71">General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>General Medicine Division, Massachusetts General Hospital, Boston, Massachusetts</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A72">Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115</wicri:regionArea>
<wicri:noRegion>Massachusetts 02115</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Marz, Winfried" sort="Marz, Winfried" uniqKey="Marz W" first="Winfried" last="Marz">Winfried Marz</name>
<affiliation wicri:level="3">
<nlm:aff id="A18">Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Mannheim Institute of Public Health, Medical Faculty of Mannheim, University of Heidelberg, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3">
<nlm:aff id="A73">Synlab Academy, Mannheim, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Synlab Academy, Mannheim</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
<affiliation>
<nlm:aff id="A74">Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz Austria</nlm:aff>
<wicri:noCountry code="subfield">Graz Austria</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Eriksson, Per" sort="Eriksson, Per" uniqKey="Eriksson P" first="Per" last="Eriksson">Per Eriksson</name>
<affiliation wicri:level="3">
<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name>
<affiliation wicri:level="2">
<nlm:aff id="A21">Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore, MD 21287 USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName>
<region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Johns Hopkins School of Medicine, Division of Internal Medicine, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name>
<affiliation wicri:level="4">
<nlm:aff id="A75">INSERM UMRS_1062, Aix-Marseille Université, Marseille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM UMRS_1062, Aix-Marseille Université, Marseille</wicri:regionArea>
<placeName>
<region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
<settlement type="city">Marseille</settlement>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author>
<name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<affiliation wicri:level="1">
<nlm:aff id="A19">Wellcome Trust Sanger Institute, Hinxton, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Sanger Institute, Hinxton</wicri:regionArea>
<wicri:noRegion>Hinxton</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1">
<nlm:aff id="A29">Department of Twin Research and Genetic Epidemiology, King's College London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Twin Research and Genetic Epidemiology, King's College London</wicri:regionArea>
<wicri:noRegion>King's College London</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Williams, Scott M" sort="Williams, Scott M" uniqKey="Williams S" first="Scott M." last="Williams">Scott M. Williams</name>
<affiliation wicri:level="2">
<nlm:aff id="A27">Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Genetics, Gesiel School of Medicine at Dartmouth, Lebanon, NH</wicri:regionArea>
<placeName>
<region type="state">New Hampshire</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation wicri:level="1">
<nlm:aff id="A3">MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland</wicri:regionArea>
<wicri:noRegion>Scotland</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="3">
<nlm:aff id="A63">Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen</wicri:regionArea>
<placeName>
<settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name>
<affiliation wicri:level="3">
<nlm:aff id="A10">Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm</wicri:regionArea>
<placeName>
<settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Lowenstein, Charles J" sort="Lowenstein, Charles J" uniqKey="Lowenstein C" first="Charles J." last="Lowenstein">Charles J. Lowenstein</name>
<affiliation wicri:level="2">
<nlm:aff id="A4">The Aab Cardiovascular Research Institute, Department of Medicine, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester, NY USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">État de New York</region>
</placeName>
<wicri:cityArea>The Aab Cardiovascular Research Institute, Department of Medicine, The University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave., Rochester</wicri:cityArea>
</affiliation>
</author>
<author>
<name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name>
<affiliation wicri:level="4">
<nlm:aff id="A34">Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Population Health Sciences and Education, St George's University of London, London SW17 0RE</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName>
<settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<affiliation wicri:level="2">
<nlm:aff id="A1">National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA USA</nlm:aff>
<country>États-Unis</country>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
<wicri:cityArea>National Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham</wicri:cityArea>
</affiliation>
<affiliation>
<nlm:aff id="A2">National Heart, Lung and Blood Institute Division of Intramural Research, Bethesda MD USA</nlm:aff>
<wicri:noCountry code="subfield">Bethesda MD USA</wicri:noCountry>
</affiliation>
<affiliation wicri:level="2">
<nlm:aff id="A64">Cardiology Division, Massachusetts General Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiology Division, Massachusetts General Hospital, Boston, MA</wicri:regionArea>
<placeName>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Arteriosclerosis, thrombosis, and vascular biology</title>
<idno type="ISSN">1079-5642</idno>
<idno type="eISSN">1524-4636</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass></textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">
<sec id="S1">
<title>Objective</title>
<p id="P3">Tissue plasminogen activator (tPA), a serine protease, catalyzes the conversion of plasminogen to plasmin, the major enzyme responsible for endogenous fibrinolysis. In some populations, elevated plasma levels of tPA have been associated with myocardial infarction and other cardiovascular diseases (CVD). We conducted a meta-analysis of genome-wide association studies (GWAS) to identify novel correlates of circulating levels of tPA.</p>
</sec>
<sec id="S2">
<title>Approach and Results</title>
<p id="P4">Fourteen cohort studies with tPA measures (N=26,929) contributed to the meta-analysis. Three loci were significantly associated with circulating tPA levels (
<italic>P</italic>
<5.0×10
<sup>−8</sup>
). The first locus is on 6q24.3, with the lead SNP (rs9399599,
<italic>P</italic>
=2.9×10
<sup>−14</sup>
) within
<italic>STXBP5</italic>
. The second locus is on 8p11.21. The lead SNP (rs3136739,
<italic>P</italic>
=1.3×10
<sup>−9</sup>
) is intronic to
<italic>POLB</italic>
and less than 200kb away from the tPA encoding gene
<italic>PLAT</italic>
. We identified a non-synonymous SNP (rs2020921) in modest LD with rs3136739 (r
<sup>2</sup>
= 0.50) within exon 5 of
<italic>PLAT</italic>
(
<italic>P</italic>
=2.0×10
<sup>−8</sup>
). The third locus is on 12q24.33, with the lead SNP (rs7301826,
<italic>P</italic>
=1.0×10
<sup>−9</sup>
) within intron 7 of
<italic>STX2</italic>
. We further found evidence for association of lead SNPs in
<italic>STXBP5</italic>
and
<italic>STX2</italic>
with expression levels of the respective transcripts. In
<italic>in vitro</italic>
cell studies, silencing
<italic>STXBP5</italic>
decreased release of tPA from vascular endothelial cells, while silencing of
<italic>STX2</italic>
increased tPA release. Through an
<italic>in-silico</italic>
lookup, we found no associations of the three lead SNPs with coronary artery disease or stroke.</p>
</sec>
<sec id="S3">
<title>Conclusions</title>
<p id="P5">We identified three loci associated with circulating tPA levels, the
<italic>PLAT</italic>
region,
<italic>STXBP5</italic>
and
<italic>STX2.</italic>
Our functional studies implicate a novel role for
<italic>STXBP5</italic>
and
<italic>STX2</italic>
in regulating tPA release.</p>
</sec>
</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Australie</li>
<li>Croatie</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region>
<li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>Californie</li>
<li>Canton de Berne</li>
<li>Caroline du Nord</li>
<li>District de Darmstadt</li>
<li>District de Karlsruhe</li>
<li>District de Tübingen</li>
<li>Grand Londres</li>
<li>Groningue (province)</li>
<li>Hesse (Land)</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>New Hampshire</li>
<li>Nouvelle-Galles du Sud</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhode Island</li>
<li>Svealand</li>
<li>Texas</li>
<li>Utrecht (province)</li>
<li>Vermont</li>
<li>Virginie</li>
<li>Washington (État)</li>
<li>Écosse</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement>
<li>Amsterdam</li>
<li>Berne</li>
<li>Francfort-sur-le-Main</li>
<li>Glasgow</li>
<li>Groningue</li>
<li>Leyde</li>
<li>Londres</li>
<li>Mannheim</li>
<li>Marseille</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Sydney</li>
<li>Ulm</li>
<li>Utrecht</li>
<li>Édimbourg</li>
</settlement>
<orgName>
<li>University College de Londres</li>
<li>Université d'Aix-Marseille</li>
<li>Université d'Édimbourg</li>
<li>Université de Glasgow</li>
<li>Université de Londres</li>
<li>Université de Sydney</li>
</orgName>
</list>
<tree>
<country name="États-Unis">
<region name="Massachusetts">
<name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name>
</region>
<name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name>
<name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M." last="Becker">Diane M. Becker</name>
<name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C." last="Becker">Lewis C. Becker</name>
<name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<name sortKey="Bookman, Ebony B" sort="Bookman, Ebony B" uniqKey="Bookman E" first="Ebony B." last="Bookman">Ebony B. Bookman</name>
<name sortKey="Chen, Fang" sort="Chen, Fang" uniqKey="Chen F" first="Fang" last="Chen">Fang Chen</name>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<name sortKey="Chen, Wei Min" sort="Chen, Wei Min" uniqKey="Chen W" first="Wei-Min" last="Chen">Wei-Min Chen</name>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<name sortKey="Cushman, Mary" sort="Cushman, Mary" uniqKey="Cushman M" first="Mary" last="Cushman">Mary Cushman</name>
<name sortKey="Destefano, Anita" sort="Destefano, Anita" uniqKey="Destefano A" first="Anita" last="Destefano">Anita Destefano</name>
<name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R." last="Folsom">Aaron R. Folsom</name>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<name sortKey="Furie, Karen L" sort="Furie, Karen L" uniqKey="Furie K" first="Karen L." last="Furie">Karen L. Furie</name>
<name sortKey="Hsu, Fang Chi" sort="Hsu, Fang Chi" uniqKey="Hsu F" first="Fang-Chi" last="Hsu">Fang-Chi Hsu</name>
<name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Kathiresan, Sekar" sort="Kathiresan, Sekar" uniqKey="Kathiresan S" first="Sekar" last="Kathiresan">Sekar Kathiresan</name>
<name sortKey="Keene, Keith L" sort="Keene, Keith L" uniqKey="Keene K" first="Keith L." last="Keene">Keith L. Keene</name>
<name sortKey="Lowenstein, Charles J" sort="Lowenstein, Charles J" uniqKey="Lowenstein C" first="Charles J." last="Lowenstein">Charles J. Lowenstein</name>
<name sortKey="Matijevic, Nena" sort="Matijevic, Nena" uniqKey="Matijevic N" first="Nena" last="Matijevic">Nena Matijevic</name>
<name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<name sortKey="Meigs, James B" sort="Meigs, James B" uniqKey="Meigs J" first="James B." last="Meigs">James B. Meigs</name>
<name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<name sortKey="Moore, Jason H" sort="Moore, Jason H" uniqKey="Moore J" first="Jason H." last="Moore">Jason H. Moore</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J." last="O'Donnell">Christopher J. O'Donnell</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M." last="Psaty">Bruce M. Psaty</name>
<name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P." last="Reilly">Muredach P. Reilly</name>
<name sortKey="Sale, Michele M" sort="Sale, Michele M" uniqKey="Sale M" first="Michèle M." last="Sale">Michèle M. Sale</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L." last="Smith">Nicholas L. Smith</name>
<name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name>
<name sortKey="Taylor, Kent" sort="Taylor, Kent" uniqKey="Taylor K" first="Kent" last="Taylor">Kent Taylor</name>
<name sortKey="Tracy, Russell P" sort="Tracy, Russell P" uniqKey="Tracy R" first="Russell P." last="Tracy">Russell P. Tracy</name>
<name sortKey="Williams, Scott M" sort="Williams, Scott M" uniqKey="Williams S" first="Scott M." last="Williams">Scott M. Williams</name>
<name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B." last="Worrall">Bradford B. Worrall</name>
<name sortKey="Yamkauchi, Munekazu" sort="Yamkauchi, Munekazu" uniqKey="Yamkauchi M" first="Munekazu" last="Yamkauchi">Munekazu Yamkauchi</name>
<name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R." last="Yanek">Lisa R. Yanek</name>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
</country>
<country name="Royaume-Uni">
<noRegion>
<name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E." last="Huffman">Jennifer E. Huffman</name>
</noRegion>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Carter, Angela M" sort="Carter, Angela M" uniqKey="Carter A" first="Angela M." last="Carter">Angela M. Carter</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Goodall, Alison H" sort="Goodall, Alison H" uniqKey="Goodall A" first="Alison H." last="Goodall">Alison H. Goodall</name>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D." last="Lowe">Gordon D. Lowe</name>
<name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L." last="Mcardle">Wendy L. Mcardle</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<name sortKey="Rudnicka, Alicja R" sort="Rudnicka, Alicja R" uniqKey="Rudnicka A" first="Alicja R." last="Rudnicka">Alicja R. Rudnicka</name>
<name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name>
<name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name>
<name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name>
<name sortKey="Shin, So Youn" sort="Shin, So Youn" uniqKey="Shin S" first="So-Youn" last="Shin">So-Youn Shin</name>
<name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<name sortKey="Soranzo, Nicole" sort="Soranzo, Nicole" uniqKey="Soranzo N" first="Nicole" last="Soranzo">Nicole Soranzo</name>
<name sortKey="Spector, Timothy D" sort="Spector, Timothy D" uniqKey="Spector T" first="Timothy D." last="Spector">Timothy D. Spector</name>
<name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J." last="Stott">David J. Stott</name>
<name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P." last="Strachan">David P. Strachan</name>
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<name sortKey="Williams, Frances M K" sort="Williams, Frances M K" uniqKey="Williams F" first="Frances M. K." last="Williams">Frances M. K. Williams</name>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
</country>
<country name="Pays-Bas">
<noRegion>
<name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
</noRegion>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W." last="Asselbergs">Folkert W. Asselbergs</name>
<name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J. M." last="De Craen">Anton J. M. De Craen</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H." last="Franco">Oscar H. Franco</name>
<name sortKey="Grant, Peter J" sort="Grant, Peter J" uniqKey="Grant P" first="Peter J." last="Grant">Peter J. Grant</name>
<name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L." last="Hillege">Hans L. Hillege</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Ikram, Mohammad A" sort="Ikram, Mohammad A" uniqKey="Ikram M" first="Mohammad A." last="Ikram">Mohammad A. Ikram</name>
<name sortKey="Ikram, Mohammad A" sort="Ikram, Mohammad A" uniqKey="Ikram M" first="Mohammad A." last="Ikram">Mohammad A. Ikram</name>
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